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ea0021p358 | Steroids | SFEBES2009

Hepatic vein cannulation and stable isotope tracer infusion reveals that liver cortisol regeneration by 11β-HSD1 is sustained in obese men with type 2 diabetes mellitus, providing a target for enzyme inhibition

Stimson Roland , Andrew Ruth , McAvoy Norma , Tripathi Dhiraj , Hayes Peter , Walker Brian

Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) are being developed to prevent cortisol regeneration from cortisone in liver and adipose tissue in type 2 diabetes (T2DM). However, the target patient group is uncertain. In obesity 11β-HSD1 activity is increased in adipose tissue but decreased in liver, as judged indirectly by plasma cortisol levels after oral cortisone administration. However, in T2DM, urinary steroid ratios suggest liver 11&#946...

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Endocrine Abstracts

Hepatic vein cannulation and stable isotope tracer infusion reveals that liver cortisol regeneration by 11β-HSD1 is sustained in obese men with type 2 diabetes mellitus, providing a target for enzyme inhibition

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